LR-CNN: Local-aware Region CNN for Vehicle Detection in Aerial Imagery

State-of-the-art object detection approaches such as Fast/Faster R-CNN, SSD, or YOLO have difficulties detecting dense, small targets with arbitrary orientation in large aerial images. The main reason is that using interpolation to align RoI features can result in a lack of accuracy or even loss of location information. We present the Local-aware Region Convolutional Neural Network (LR-CNN), a novel two-stage approach for vehicle detection in aerial imagery. We enhance translation invariance to detect dense vehicles and address the boundary quantization issue amongst dense vehicles by aggregating the high-precision RoIs' features. Moreover, we resample high-level semantic pooled features, making them regain location information from the features of a shallower convolutional block. This strengthens the local feature invariance for the resampled features and enables detecting vehicles in an arbitrary orientation. The local feature invariance enhances the learning ability of the focal loss function, and the focal loss further helps to focus on the hard examples. Taken together, our method better addresses the challenges of aerial imagery. We evaluate our approach on several challenging datasets (VEDAI, DOTA), demonstrating a significant improvement over state-of-the-art methods. We demonstrate the good generalization ability of our approach on the DLR 3K dataset.Comment: 8 page

Vitexin alleviates neuropathic pain in a mouse chronic constriction injury model by inactivation of NF-κB

Purpose: To investigate the therapeutic effect of vitexin on neuropathic pain (NP) in a mouse model of chronic constriction injury (CCI).Methods: The CCI model was established by four chronic ligatures in the sciatic nerve. Vitexin was intraperitoneally administered (10 mg/kg, once daily) for 21 days. Mechanical withdrawal threshold (MWT) and paw withdrawal latency (PWL) were determined before and after the establishment of CCI model. The spinal cords were collected to measure mRNA levels by reverse-transcriptase polymerase chain reaction (RT-PCR) enzyme-linked immunosorbent assay (ELISA). Western blot was used to examine protein expression levels.Results: Vitexin reversed the CCI-induced reduction in MWT and PWL values, indicating that it lowered mechanical hypersensitivity response and hyperalgesia caused thermal stimulation (p < 0.05). The elevated levels of IL-6, IL-1β, and TNFα observed in CCI-treated mice were also inhibited by vitexin, suggesting that it suppressed pro-inflammatory cytokines. Moreover, vitexin attenuated CCI-induced activation of NF-κB signaling in CCI-treated mice (p < 0.05).Conclusion: Vitexin alleviates NP by inhibiting pro-inflammatory cytokines and NF-κB signaling in CCItreated mice. Thus, it is a potential target for NP treatment. Keywords: Vitexin, Neuropathic pain, Chronic constriction injury, Mechanical hypersensitivity, Hyperalgesia, NF-κ

Bis(4H-1,2,4-triazol-3-yl)disulfane

The title compound, C4H4N6S2, was synthesized by the reaction of 3-mercapto-1H-1,2,4-triazole with sodium hydrox­ide in ethanol. The mol­ecule possesses a crystallographically imposed twofold axis. Inter­molecular N—H⋯N hydrogen bonds link the mol­ecules into chains along the c axis

N,N′-Dibenzyl-N,N,N′,N′-tetra­methyl­ethylenediammonium dibromide dihydrate

In the title compound, C20H30N2 2+·2Br−·2H2O, the asymmetric unit consists of half of the N,N′-dibenzyl-N,N,N′,N′-tetra­methyl­ethylenediammonium cation lying across an inversion center, a bromide ion and a water mol­ecule of solvation. There is an eight-membered dibromide dihydrate ring, which is formed via hydrogen bonds of the type O—H⋯Br

Open-source genomic analysis of Shiga-toxin–producing E. coli O104:H4

An outbreak caused by Shiga-toxin–producing Escherichia coli O104:H4 occurred in Germany in May and June of 2011, with more than 3000 persons infected. Here, we report a cluster of cases associated with a single family and describe an open-source genomic analysis of an isolate from one member of the family. This analysis involved the use of rapid, bench-top DNA sequencing technology, open-source data release, and prompt crowd-sourced analyses. In less than a week, these studies revealed that the outbreak strain belonged to an enteroaggregative E. coli lineage that had acquired genes for Shiga toxin 2 and for antibiotic resistance

Glycated Haemoglobin A1c Variability Score Elicits Kidney Function Decline in Chinese People Living with Type 2 Diabetes

Our aim was to investigate the association of glycated haemoglobin A1c (HbA1c) variability score (HVS) with estimated glomerular filtration rate (eGFR) slope in Chinese adults living with type 2 diabetes. This cohort study included adults with type 2 diabetes attending outpatient clinics between 2011 and 2019 from a large electronic medical record-based database of diabetes in China (WECODe). We estimated the individual-level visit-to-visit HbA1c variability using HVS, a proportion of changes in HbA1c of ≥0.5% (5.5 mmol/mol). We estimated the odds of people experiencing a rapid eGFR annual decline using a logistic regression and differences across HVS categories in the mean eGFR slope using a mixed-effect model. The analysis involved 2397 individuals and a median follow-up of 4.7 years. Compared with people with HVS ≤ 20%, those with HVS of 60% to 80% had 11% higher odds of experiencing rapid eGFR annual decline, with an extra eGFR decline of 0.93 mL/min/1.73 m(2) per year on average; those with HVS > 80% showed 26% higher odds of experiencing a rapid eGFR annual decline, with an extra decline of 1.83 mL/min/1.73 m(2) per year on average. Chinese adults with type 2 diabetes and HVS > 60% could experience a more rapid eGFR decline